What is prosopagnosia and who can it affect?

A face says a lot about a person. But what if your brain is not able to process this information? We tell you what prosopagnosia is.

Last update: September 14, 2021

Prosopagnosia is the inability to identify people by their faces. Those affected do not recognize the faces of people they knew before, nor do they become familiar with those they have just met.

When this occurs due to brain injury, we talk about acquired prosopagnosia. If there is no obvious neurological damage or generalized cognitive deficit and the defect is present from infancy, then it is a developmental prosopagnosia or congenital.

Symptoms and characteristics of prosopagnosia

People with prosopagnosia have an inability to recognize and discriminate faces with different degrees of disease. They do not recognize public figures or celebrities, but neither do they recognize those closest to them, including their partner and children. In severe cases, may not recognize themselves in the mirror.

It should be clarified that the affected process is the ability to establish people's identity through the information on their face, but the ability to process other facial information, such as expressions and emotions, is intact. They know they are in front of a face, but they cannot know who it is or if they have seen it before.

How to tell if a person has prosopagnosia

Murray and colleagues interviewed adults and parents of children affected by developmental prosopagnosia and constructed a list of symptoms. The most relevant thing they found was the following:

  • They are unable to identify people in photographs.
  • People with similar extra facial features are confused, although their faces are very different.
  • They describe people using extra facial information, but avoid calling people by their names.
  • Their difficulty in identifying people is compounded when they share a characteristic such as being the same age, the same sex, or wearing a uniform.
  • They ignore people they know in public if they are found accidentally.
  • It is easier for them to recognize people in familiar surroundings (for example, the workplace), but it is difficult for them if they are found outside of this place.
  • Can't describe the face of a person.
  • They are not able to recognize a person if they change their haircut or style.

In the place www.prosopagnosiaresearch.org a symptom checklist can be found.

Differences between acquired and developmental prosopagnosia

In acquired prosopagnosia, the condition is more severe than in developmental disease. The reason is not completely clear. But there are several hypotheses.

One is that people with developmental prosopagnosia have more time to practice compensatory behaviors. Others are that the lesions of patients with the acquired form are usually serious and affect the brain areas of face processing to a greater extent.

Severe cases of the disease present with the inability of the patient to recognize himself in the mirror.

What causes prosopagnosia?

There are many factors involved in the brain processing of information from a face. This is reflected in the complexity of variables that intervene in the appearance of prosopagnosia.

First, the person perceives that he is facing a particular face. To do this, he checks it against the information stored in his brain about the structure of a face.

This face is then compared with those stored in memory to determine if it has been seen before. Finally, the person is identified and their name and biographical information are accessed.

Based on this model, prosopagnosia is usually divided into variants. When the affected person is not able to perceive the differences between the faces of different people, they speak of apperceptive prosopagnosia. If you cannot determine whether you have seen the face before or associate the perceived information with identifying a person, then it is a amnesic prosopagnosia or associative.

Neuroanatomy of acquired prosopagnosia

Acquired prosopagnosia is probably not a unique disorder. Instead, it is a group of disorders that have the same outcome in common.

Various brain regions are involved in processing faces. Therefore, there are a variety of lesions capable of causing prosopagnosia. The classic injury that is the bilateral damage of certain areas of the occipitotemporal cortex.

Other conditions that may be related to the development of prosopagnosia are herpetic encephalitis, surgeries for the treatment of epilepsy, tumor resection or cerebral hemorrhages. If anything, the evidence suggests that structural and functional integrity of all brain regions is needed linked to face recognition for normal performance.

Brain basis of developmental prosopagnosia

By definition, people with developmental prosopagnosia should have no obvious lesions. However, it is postulated that they present alterations in brain tissues that are not seen in conventional imaging studies.

These abnormalities may be present in the areas involved in brain processing of faces or in the connections between them.

There are families in which various members through the generations are affected. Because of this, developmental prosopagnosia is suspected to have a genetic basis and a dominant hereditary component.

In fact, Wilmer et al. Found that monozygotic twins share 70% of their ability to recognize faces. Meanwhile, dizygotic twins only 29%. This means that the researchers' findings support a crucial effect of genes.

Possible consequences and impacts

According to Jenkins et al., An average person recognizes 5,000 faces. This ability to identify and recognize people is key to interpersonal relationships.

So those who have prosopagnosia have traumatic and stressful social experiences for his inability to recognize people. This leads to them isolating themselves, avoiding meetings and crowds, and having a limited social circle.

Those affected have anxiety, depression, other mood disorders, feelings of shame and guilt. In children it affects their school performance. They can present exaggerated fear of strangers and separation anxiety.

How is prosopagnosia diagnosed?

To diagnose this entity face familiarity tests are used. These assess the ability to recognize faces that have been seen before.

The most used is the Cambridge face recognition test (Cambridge Face Memory Test). In this test, the participant performs a series of tasks that are increasing in complexity. You are asked to memorize faces and to discriminate familiar faces from others that are not.

They are also used questionnaires to measure the social impact of the disease in everyday activities, such as prosopagnosia index (PI20). However, there are no useful laboratory tests for the diagnosis of prosopagnosia.

Diagnostic criteria for prosopagnosia

A person is said to have prosopagnosia if the following criteria are present:

  • Presence of difficulty recognizing faces.
  • Impairment of the ability to recognize faces objectively measured on at least two familiarity tests.
  • In the case of acquired prosopagnosia, confirmation of a lesion through an imaging study, like MRI or CT scan.

Differential diagnostics

A key point when diagnosing prosopagnosia is to rule out any other disease that may explain the symptoms. It must be confirmed that there is no vision or memory problem.

Similarly, such difficulty in recognizing faces may exist in the context of other pathologies. In children, we find, for example, autism spectrum disorders.

In adults, schizophrenia, Parkinson's disease and Alzheimer's disease, among others. On the other hand, if the patient is able to recognize that he has seen a face before, even though he cannot give his name, this is not prosopagnosia.

Treatment and lifestyle

There is a possibility that there is a reorganization or modulation of the neural network responsible for face recognition. In this way, a rehabilitation would be possible.

So the approach to people with prosopagnosia has two approaches:

  • The development of strategies with which to compensate for its deficit.
  • Try to improve memory and perception.

A multidisciplinary accompaniment of the affected person is recommended that includes a neurologist, psychologist, psychiatrist and social worker. The goal is for this person to have the best possible quality of life.

Can prosopagnosia be cured?

In rare cases, acquired prosopagnosia resolves on its own. While developmental prosopagnosia persists throughout life.

Given the heterogeneity of presentations, a specific treatment program may not be useful for all those affected. Each will have a different rehabilitation potential.

In acquired prosopagnosia, the efficacy of therapy will depend on the age at which it appeared, the time that has passed since then, the size of the lesion, the side of the brain affected, and the location.

In the acquired form, the patient must present some objective lesion that can be detected by imaging methods.

Oxytocin and prosopagnosia

Oxytocin is a hormone involved in the regulation of social and reproductive behavior. For this reason, its therapeutic utility in various diseases has been explored.

Although there are no drugs or medications approved to treat prosopagnosia, Bate et al. Conducted a study with inhaled intranasal oxytocin, obtaining favorable results. In those affected by developmental prosopagnosia improved test performance that measured the recognition and identification of faces.

A rare disease that affects relationships

Prosopagnosia can affect your everyday life. But this can change if you receive the appropriate social and professional support.

If you recognize any of the symptoms or situations described in this article, do not hesitate to ask for help and consult your doctor. A team of several professionals will be able to guide you.