Tryptizol ®: what it is, what it is for and side effects

The use of Tryptizol ® must be ordered and supervised by a doctor. This medication has the potential to cause significant side effects and interactions and should be used with extreme caution.

Last update: 03 September, 2021

Tryptizol ® is the brand name of an antidepressant medicine, whose active substance is amitriptyline. This drug is also used as a pain reliever on some occasions. It works by preventing the reuptake of norepinephrine and serotonin, which helps a feeling of well-being.

Currently there is a high consumption of antidepressants. While these medications are a great help, it has also become common for them to be ingested in excess. Hence the importance of knowing its characteristics and possible risks.

What is Tryptizol ®?

Tryptizol ® is a drug that belongs to the tricyclic antidepressant family. It comes in coated tablets, which they are round, biconvex and yellow in color. It is usually found in packs of 24 or 60 pills.

The active substance in Tryptizol ® is amitriptyline. This substance prevents the reuptake of serotonin and norepinephrine in nerve endings. Thanks to this, the levels of these neurotransmitters are increased, which affects the mood.

Both serotonin and norepinephrine are associated with motivation, reducing stress and anxiety. Even serotonin has been called the hormone of happiness. On the other hand, Tryptizol ® also has analgesic effects.

What is Tryptizol® for?

Tryptizol ® is almost always used as an antidepressant, but also as an analgesic. The most common is that it is used in the treatment of conditions such as the following:

  • Episodes of major depression in adults.
  • Chronic headaches and migraines.
  • Neuropathic pain, such as that caused by diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia.
  • Urinary incontinence in children, if it is not associated with organic causes.

Sometimes, Tryptizol ® is also used to treat sleep disorders. Likewise, it may be prescribed for people with bipolar disorder, but it can alter the manic phase. It is also used for schizophrenia, although it is possible that it aggravates some of its symptoms.

The priority use of amitriptyline is in depression, although it is also analgesic.


What are the side effects of Tryptizol ®?

Some of the people who use Tryptizol ® may gain or lose weight from taking the drug. Common side effects are as follows:

  • Headache
  • Drowsiness or numbness with slow speech.
  • Dizziness when standing up
  • Nausea, constipation, or diarrhea.
  • Dry mouth and nasal congestion.
  • Sweating
  • Trembling in the hands or other parts of the body.

A little less frequent are the following effects: sexual dysfunction, tingling or numbness in the arms and legs, changes in the sense of taste, low concentration of sodium in the blood and feeling thirsty. Much less common are seizures, increased blood pressure, skin rash and hives, secretion of breast milk without lactation, and glaucoma.

In a worst-case scenario, 1 in 1000 people may experience delirium and hallucinations, abnormal heart rhythms, increased sensitivity to sunlight, and fever. Paranoia and hepatitis are also rare reactions.

Tryptizol ® contraindications

It is not advisable to ingest Tryptizol ® during pregnancy or lactation. There is a possibility that the active substance reaches the baby through the placenta or breast milk.

The use of this drug is not recommended in the following cases:

  • Having recently suffered a myocardial infarction.
  • If monoamine oxidase inhibitors (MAOIs) were taken in the last 14 days.
  • In case of severe liver disease.
  • Being sensitive or allergic to lactose.

It is not advisable to drink alcohol while the treatment with Tryptizol ® lasts.. This can increase the sedative effect. This drug should be used with great caution by those who drive or work with machines.

Several medications cannot be combined with amitriptyline. This is the case of MAOIs.

Interaction of Tryptizol ® with other medications

There are some medications that can interact with Tryptizol ® and cause serious adverse effects. In addition to the MAOIs, which were already outlined in the previous section, the doctor should be informed if one or more of the following drugs are being used:

  • Adrenaline, ephedrine, isoprenaline, norepinephrine, phenylephrine, and phenylpropanolamine.
  • Anticholinergic drugs.
  • Tramadol.
  • Other antidepressants.
  • Ritonavir.
  • Rifampicin
  • Phenytoin and carbamazepine.
  • Grass of San Juan (Hypericum perforatum).
  • Methadone.

Likewise, the patient you must inform that you are taking Tryptizol ® if you are going to undergo surgery or to any dental procedure that requires the use of anesthesia.



Always with a prescription

It is important to emphasize that Tryptizol ® should only be used under strict prescription and medical supervision. As we have seen, it can have significant side effects as well as risky interactions.

This article is for informational purposes only. We invite you to go to a health professional to treat your specific case.