These are the symptoms that persist among those recovered from COVID-19

It is not yet clear the long-term health consequences of COVID-19. However, the study carried out by the work team that faced the first situations at the Jin Yin-tan Hospital, Wuhan, Hubei, allows us to describe some. The risk factors associated with the disease indicate which are the symptoms that persist among those recovered and these depend on the severity of the disease.

Ambidirectional cohort analysis was conducted at the first designated hospital for COVID-19 patients in Wuhan, Hubei, China. For which all laboratory-confirmed coronavirus patients who were discharged from the hospital between January 7 and May 29, 2020.

Excluding the following patients: those who died before the follow-up visit, those who refused to participate. Also those for whom the study follow-up would be very difficult due to a psychotic disorder, dementia or hospital admission attributed to underlying diseases.

Collecting a total of 1733 enrolled from 2469 patients discharged with COVID-19 after six months of discharge. For the total, the average age was 57 years and 52% were men.

The data

The follow-up time after the appearance of the first COVID-19 symptoms it was 186 days. And the results of the study are as follows:

  • Muscle fatigue or weakness (63%)
  • Sleeping difficulties (26%)
  • Anxiety or depression in 23%

On the other hand, the proportions of the median distance covered in 6 minutes below the lower limit of the range were in recovered patients:

  • 24% for those on severity scale 3.
  • 22% for severity scale 4.
  • 29% for severity scale 5-6.

And the corresponding proportions of patients with impaired diffusion were:

  • 24% for severity scale 3.
  • 29% for scale 4.
  • 56% for scale 5-6.
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Conclusions about symptoms

This cohort study is the largest with the longest duration of follow-up. Especially referring to the health consequences of discharged adult patients. But even so, the following conclusions were reached. After 6 months having had COVID-19 most of the recovered patients faced at least one symptom. In particular, the muscle fatigue or weakness, trouble sleeping, and depression or anxiety.

While recovered patients who suffered from the disease in serious condition were at increased risk of abnormalities in the pulmonary diffusion or similar symptoms. It was also observed that seropositivity and neutralizing antibody titers were significantly lower than in the acute phase.

On the other hand, it was highlighted that women had higher risk factors for developing persistent psychological symptoms. Whether the remaining radiological or pulmonary diffusion abnormalities fully resolve in further follow-up studies remains to be investigated.

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