The Rivotril It is one of the trademarks under which clonazepam is marketed, an active substance that belongs to the benzodiazepine family.
This medicine acts in the central nervous system to combat, mainly, seizures, anxiety states and clinical pictures that present mood alterations.
Rivotril is also effective in preventing absences, Lennox-Gastaut syndrome, akinetic and myoclonus seizures, as well as myoclonus that occurs at night. However, it is not effective for the treatment of generalized tonic-clonic seizures.
In this way, the Rivotril indicated when patients have not responded to other treatments for myoclonic seizures.
The first benzodiazepine was discovered in 1949 by scientist Leo Sternbach and was later synthesized by Roche laboratories in 1955. This same laboratory is the same one that synthesized 30 years later the clonazepam.
What is epilepsy?
To better understand the effect of clonazepam, it is important to understand the pathology for which Rivotril is indicated. In this sense, Epilepsy is a disease that affects the Central Nervous System, causing brain activity to stop functioning properly..
Thus, the organism may convulse or the patient may suffer periods of behavior or rare sensations. There are even times when consciousness is lost.
There is two main types of seizures:
Focal seizures: they occur because, apparently, only part of the brain is affected. They can attend with loss of consciousness or without alteration in it.
Generalized seizures: are those that, apparently, occur in all areas of the brain. In turn, they can be classified as absence, tonic, atonic, clonic, myoclonic and tonic-clonic.
How does Rivotril exert its effect on the body?
The Rivotril, or where appropriate the clonazepam, It acts in different parts of the brain triggering a sedative, hypnotic and anticonvulsant action. To achieve these effects and, therefore, be effective in the treatment of the indications described, Rivotril interacts with the GABA receptors.
GABA is a neurotransmitter of the brain, that is, a substance that acts as a messenger in the nervous system. It transmits neurotransmission signals, which are the transmission of information from one neuron to another. In the case of GABA, it transmits inhibitory signals.
With others words, GABA reduces or inhibits neuronal activity, so it plays an important role in behavior, in the response to stress and in anxiety.
During an epileptic picture, this neurotransmitter is in low concentrations, so that Rivotril, by enhancing the action of GABA, improves these pathological conditions. However, studies on the action of GABA in this disease continue.
Read also: Neurotransmitters
Rivotril adverse reactions
On the other hand, it is important to keep in mind that, at chronic and high doses, it can worsen the cognitive function of patients. It is a very addictive drug and produces great tolerance. Thus, It is administered for brief periods of time.
Also produces physiological dependence, with the consequent withdrawal syndrome, if the drug is withdrawn abruptly. In the most severe cases, death can result from this syndrome. It is for this reason that the dose of all benzodiazepines should be withdrawn gradually, never suddenly.
Most of the adverse reactions associated with Rivotril treatment they are due to its effect on the central nervous system. Among them, are:
In addition, it produces, in a paradoxical way, a stimulation of this same system, which can trigger sleep problems, euphoria, rage attacks and hostility. However, these adverse reactions are usually more frequent in psychiatric patients and in hyperactive children.
Other adverse reactions described in clinical trials with clonazepam were:
Bradycardia and hypotension.
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Rivotril is the trademark of the active substance clonazepam. Among other indications, it is used for the treatment of epilepsy, a disease whose origin is in the central nervous system.
You can consult with the doctor any questions that you have about this medicine, as well as communicate any symptoms you feel since you started treatment with it.