Scientists at King's College in London (United Kingdom) have been investigating a method to stimulate the repair of teeth by activating dental cells that they would create new dentin and they think it could be applied in the real world soon.
In an article published in the scientific journal 'Journal of Dental Research', researchers report their advances and point out that they have found more positive evidence that the method has the potential to be translated into a direct clinical approach.
When teeth suffer damage either from tooth decay or trauma, there are three layers that may be affected: the enamel Exterior; the dentine, which protects the vital part of the tooth; and the inner part of the tooth, the soft dental pulp. Previous research had found that the drug Tideglusib could help protect the inner layer by stimulating dentin production, helping the tooth repair itself.
The research team has now analyzed whether the volume of repair dentin produced is sufficient to repair decay found in human teeth. They have also investigated the range and safety of this drug, and if the mineral composition of the dentin produced is similar to that of normal dentin and is capable of maintaininger the firmness and strength of the tooth.
"We can stimulate natural dental repair by activating resident dental stem cells. This approach is simple and cost effective."
The results of this study are hopeful, since they show more evidence that the method could be translated successfully into clinical practice. The researchers found that the repair area does not affect the dental pulp and that the mineral composition of the dentin produced was significantly different from that of the bone and more similar to normal dentin.
In addition, they found that the medication can activate repair of an area of dentin damage up to ten times larger, mimicking the size of small lesions in humans. "In recent years we have shown that we can stimulate natural dental repair by activating resident dental stem cells. This approach is simple and cost effective. The latest results show more evidence of clinical viability and bring us one step closer to natural dental repair," he says. SciTechDaily Paul Sharpe, director of the Center for Craniofacial and Regenerative Biology at King's College London.
However, this treatment has not yet been tested on humans and obviously not offered by any dental specialist.