Lomotil: indications and contraindications

Lomotil is the trademark of a drug that has an active substance, loperamide. It is an oral medication used mainly for the treatment of diarrhea.

Lomotil helps reduce the number and frequency of bowel movements. Its action, although we will see it later in more detail, is to decrease bowel movement.

However, It should not be used to treat diarrhea caused by different types of infections, like the one triggered by Clostridium difficile.

Further, The use of this medicine is discouraged in children under 6 years old due to an increased risk of presenting serious side effects, such as those we will see throughout the article.

Why does diarrhea occur?

Diarrhea consists of evacuating soft or loose stools frequently. It is a clinical picture that usually does not last long and generally improves on its own. Normally, it is due to an intestinal infection, the most common pathogens being viruses and bacteria.

However, also may be a consequence of a diet high in sugars, some food allergy, lactose intolerance and intestinal problems such as celiac disease or inflammatory bowel diseases.

A person suffering from diarrhea may suffer stomach pains or cramps, followed by diarrhea that normally lasts 3 to 5 days. In addition, it is also common to trigger any of the following symptoms:

  • Fever.
  • Loss of appetite
  • Sickness.
  • Dehydration
Lomotil is a medicine used against diarrhea episodes. It serves to reduce the number and frequency of bowel movements.

Mechanism of action: how does Lomotil exert its effect on the organism?

As we know, the Lomotil helps reduce the number and frequency of bowel movements. Its action is to decrease bowel movement. Lomotil an active substance, loperamide, which will help achieve the therapeutic goal.

By decreasing the number of bowel movements, the speed of digestion is gently recovered. Thus, proper absorption of liquids is allowed, Restoring stool consistency.

The Lomotil acts effectively to control diarrhea from the first symptoms. Loperamide interferes with peristalsis, by direct action on the circular and intestinal muscles, reducing their motility.

It also acts by reducing the secretion of fluids and electrolytes and increasing water absorption. By increasing transit time and reducing fluid loss, loperamide increases stool consistency and reduce fecal volume.

And, although loperamide is chemically related to opioid drugs, This active substance has no analgesic effects even at high doses. However, children under three years of age may be more sensitive to these effects.

Read also: Chronic and acute diarrhea: causes and treatment

Contraindications of Lomotil

Lomotil and, therefore, loperamide, like other drugs that have the same effects, can induce the development of toxic pictures in the colon in patients who have ulcerative colitis.

Therefore, these patients should have special vigilance in case toxicity symptoms appear. Further, This medication is contraindicated when diarrhea is a consequence of pseudomembranous colitis., as well as in diarrhea caused by enteric microorganisms.

On the other hand, patients with liver disease should be monitored with greater attention, since loperamide levels can increase, since it is metabolized in the liver.

Finally, it is important to mention that still It is not known if this active substance is excreted in breast milk. For this reason, caution should be exercised during breastfeeding.

Lomotil is contraindicated in patients with ulcerative colitis; In addition, it should be avoided if diarrhea is a consequence of pseudomembranous colitis or infections by enteric microorganisms.

Adverse reactions

Lomotil treatment can cause a series of adverse reactions, As with treatment with any medication. We understand adverse effects like all those undesirable and unintended events that occur with drug treatment.

In this sense, loperamide can cause:

  • Drowsiness.
  • Dizziness
  • Headache.
  • Dry mouth.
  • Blurry vision.
  • Loss of appetite

In addition to those mentioned, other more serious side reactions can also be triggered, such as:

  • Changes in mood.
  • Stomach pain and inflammation.
  • Numbness or tingling in the arms or legs.

You may also be interested in reading: Risks of self-medication


Lomotil is a medicine that Contains loperamide as active ingredient. It is used for the treatment of diarrhea, since it has the ability to reduce the number of bowel movements and increase their consistency.

Consult with the doctor any questions you have about the treatment with this medicine, as well as any discomfort that arises after starting treatment with it.

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