Aceclofenac: what is it and what are its effects

Aceclofenac is a non-steroidal anti-inflammatory drug or NSAID widely used for the relief of pain and inflammation associated with rheumatological diseases. Presents analgesic, anti-inflammatory and antirheumatic effects.

Chemically speaking, is an aryl derivative of acetic acid. Its structure is related to another analgesic drug, diclofenac.

This drug it is prescribed in cases in which a treatment is required for inflammatory processes and painful such as low back pain, toothache and joint pain.

Likewise, It is indicated for the chronic treatment of pain and inflammation associated with chronic joint processes: osteoarthritis, rheumatoid arthritis and spondylitis.

What is Rheumatoid arthritis?

Rheumatoid arthritis is a chronic inflammatory disease of autoimmune nature. It is characterized by the involvement of many joints and the development of several general and nonspecific symptoms.

If it is not treated properly, this disease can cause important physical limitations, significantly worsening the quality of life of patients.

As for the symptoms, Rheumatoid arthritis typically manifests with pain and stiffness or difficulty of movement in the different small and large joints.

The general symptoms, which sometimes precede joint manifestations and they tend to persist throughout the evolution of the disease, include, among others:

  • Fatigue.
  • Light fever
  • Feeling unwell.
  • Inappetence
  • Weightloss.

However, The most frequent initial symptom is morning joint stiffness, especially on the feet and hands.

The triggering causes of rheumatoid arthritis are still unknown. Yes it is known, as we have said, that it is an autoimmune disorder and that in their origin other causes and genetic factors intervene, as well as non-genetic causes.


This is another disease for which aceclofenac is indicated. It is another rheumatic pathology that damages the cartilage of the joints.

Inside the joints, there is a fluid known as synovial fluid that is produced by the synovial membrane. The ends of the bones that join to form the joint are covered by the articular cartilage.

When this cartilage is injured, pain, stiffness and functional disability occur. It is important to differentiate this disease from arthritis. The latter is developed by an inflammation of the joint, not by the wear of the cartilage.

However, both suffer with pain, so that aceclofenac is effective for the treatment of the symptoms of both.

Read also: What is the difference between arthritis and osteoarthritis?

And ankylosing spondylitis?

It is another rheumatic disease that causes inflammation of the joints of the spine and the sacroiliac. The exact cause of this condition is unknown, but some specialists have related it, in specific cases, to genetic inheritance.

It usually manifests in adolescence or youth and its incidence is higher in men. On the contrary, women can present the disease in a milder way, making their diagnosis more difficult.

It usually manifests with stages of back pain They can affect the entire spine and the peripheral joints, causing pain in both, spinal stiffness, loss of mobility and progressive joint deformity.

How does aceclofenac exert its effect on the body?

The anti-inflammatory effects of aceclofenac may be a consequence of the inhibition of prostaglandin synthesis, by blocking the enzyme cyclooxygenase.

Prostaglandins are protein structures that are present in numerous processes of the body, as in the sensation of pain. So that By inhibiting its synthesis, the sensation of pain also decreases.

Aceclofenac also has an antipyretic effect, which may be due to peripheral dilation caused by a central action on the hypothalamus. Other effects due to the inhibition of prostaglandin synthesis are:

  • Decreased protection of the gastric mucosa: aceclofenac can produce gastric ulcers as an adverse reaction.
  • Impaired renal function.
  • Inhibition of platelet aggregation.

Discover: What are the differences between ibuprofen and paracetamol?


The aceclofenac is a drug belonging to the family of NSAIDs used mainly to treat episodes of pain in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

However, like the rest of the drugs, presents a series of adverse reactions that must be controlled as gastrointestinal alterations and occasional dizziness. Check with your doctor or pharmacist for any questions about this medicine if you are going to be treated with it.